Rendering protein-based particles transiently insoluble for therapeutic applications.
نویسندگان
چکیده
Herein, we report the fabrication of protein (bovine serum albumin, BSA) particles which were rendered transiently insoluble using a novel, reductively labile disulfide-based cross-linker. After being cross-linked, the protein particles retain their integrity in aqueous solution and dissolve preferentially under a reducing environment. Our data demonstrates that cleavage of the cross-linker leaves no chemical residue on the reactive amino group. Delivery of a self-replicating RNA was achieved via the transiently insoluble PRINT protein particles. These protein particles can provide new opportunities for drug and gene delivery.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 134 21 شماره
صفحات -
تاریخ انتشار 2012